Physiological Changes in Hippocampal CA3-CA1 Network Following Pilocarpine Induced Status Epilepticus
Abstract
Status Epilepticus has been shown to increase the risk of developing epilepsy later in life. Anatomical changes such as dendritic instability and reduction in neurotransmitter associated vesicles have been found within the hippocampus. In this study, local field potential recordings in hippocampal slices were measured to determine how the anatomical variation between control and status epilepticus induced animals correlated to function changes in synaptic efficacy and plasticity. Rats and mice induced with status epilepticus were found to have decreased synaptic efficacy, but appeared to demonstrate varying plasticity compensation at different stimulation intensities.
Degree
M.S.
Advisors
Bartlett, Purdue University.
Subject Area
Neurosciences
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