Geometrical analysis of interaction sites of proteins
Abstract
Bioinformatics is an interdisciplinary research area between biological science and mathematics, physics, statistics, and computer science to simulate, compute, and predict biological scientific concepts. Proteomics is a branch of bioinformatics research that focus on the structure and function of proteins. This dissertation focuse on the geometrical analysis of interaction sites of proteins, studying four proteomics research problems using protein surface representations. The major contributions are: 1. Benchmark analysis of a fast protein tertiary structure retrieval method based on global surface shape similarity; 2. Development of a method for characterization of local geometry of protein surfaces using a visibility criterion; 3. Improved protein-protein docking prediction accuracy using predicted protein-protein interface information; and 4. Proposal of a new method for flexible docking using the CABS model.
Degree
Ph.D.
Advisors
Kihara, Purdue University.
Subject Area
Bioinformatics
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