Mechanistic investigation of gamma-tocotreinol-mediated anti-inflammatory actions

Yun Wang, Purdue University

Abstract

Inflammation has been linked to many degenerative diseases such as asthma, colitis and arthritis. It is very important to develop anti-inflammatory agents with low toxicity to attenuate or inhibit inflammation. Fat-soluble vitamin E consists of eight natural forms i.e., α-, β, γ-, δ- tocopherol and α-, β, γ-, δ-tocotrienol. Besides anti-oxidant properties, certain forms of vitamin E such as γ-tocopherol have been shown to have anti-inflammatory effects by inhibiting eicosanoid and cytokine production in animal models. Further studies in cell models demonstrated that specific forms of vitamin E and metabolites inhibit 5-lipoxygenase (5-LOX) and cyclooxygenase (COX) mediated proinflammatory pathways. Here we systemically investigated the anti-inflammatory effects and mechanisms of different forms of vitamin E in chemokine-stimulated lung epithelial cell, A549 cells, and endotoxin or cytokine-activated macrophages. (Abstract shortened by ProQuest.)

Degree

Ph.D.

Advisors

Jiang, Purdue University.

Subject Area

Cellular biology|Nutrition

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