Evaluation of Suspensions Using Electrokinetic Measurements
Abstract
The methods used to evaluate pharmaceutical suspensions have generally consisted of measurements of pH, viscosity, sedimentation, and particle size. While yielding some information, these measurements do not indicate why one suspension will flocculate and another suspension remain stable. The above measurements are not of value when it is desirable to predict the stability of a suspension or quantitatively evaluate a series of suspensions. Therefore, there is a need for a method that will enable the stability of the suspension to be estimated and to evaluate a series of formulas.Studies of non-pharmaceutical suspensions have shown that the electrokinetic properties of a preparation are important in determining whether a suspension or flocculation will be obtained. This paper will be concerned with the measurement of the electrokinetic properties of a pharmaceutical suspension and attempt to relate these properties to the evaluation of the suspension. The electrokinetic measurements include zeta potential and critical potential values and the effect on the zeta potential of various concentrations of suspending agent. In addition, a rate of sedimentation was performed to qualitatively show any agglomeration that may have taken place in the suspension. The pH, viscosity, and static sedimentation was measured along with the previous measurements.
Degree
Ph.D.
Subject Area
Pharmacology
Off-Campus Purdue Users:
To access this dissertation, please log in to our
proxy server.