A STUDY OF THE FACTORS INFLUENCING THE RELEASE OF LEAD FROM THE TISSUES OF THE MOUSE
Abstract
It has been found possible to obtain the same results, within reasonable limits, from the use of the very rapid and convenient nolarographic method of lead analysis, when the amount of lead per sample approximates one milligran, and the widely accepted, but time-consuming dithizone method. These data have justified the use of the former method for this work.Dietary calcium, vitamin D and phosphorus, as well as changes are the reaction of the diet, are ineffectual in the release of lead previously deposited in the tissues of adult mice. This is true after one week or after three weeks on diets containing appropriate amounts of these agents.An experiment including but two groups of mice indicated that vitamin C, under the conditions maintained, caused a remarkable improvement, physically, of previously "leaded" mice, but did not accelerate lead excretion. The suggestion of Holmes et al (23) that a slightly joined complex formed by the interaction of lead and vitamin C is given as a possible explanation of the results observed.
Degree
Ph.D.
Subject Area
Biochemistry
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