Abstract

The therapeutic efficacy of two novel short antimicrobial and anti-inflammatory peptides (RR and RRIKA) was evaluated in a mouse model of staphylococcal skin infection. RR (2%) and RRIKA (2%) significantly reduced the bacterial counts and the levels of proinflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-6, in methicillin-resistant Staphylococcus aureusUSA 300-0114 skin lesions. Furthermore, the combined therapy of RRIKA (1%) and lysostaphin (0.5%) had significantly higher antistaphylococcal and anti-inflammatory activity compared to monotherapy. This study supports the potential use of these peptides for topical treatment of methicillin-resistant Staphylococcus aureus skin infections.

Comments

This is the published PDF version of Mohamed, M.F., and Seleem, M.N. (2015). Efficacy of Short Novel Antimicrobial and Anti-Inflammatory Peptides in a Mouse Model of Methicillin-Resistant Staphylococcus aureus (MRSA) Skin Infection. Journal of Drug Design, Development and Therapy, 8, 1979-1983, http://dx.doi.org/10.2147/DDDT.S72129.

CC-BY-NC 3.0 U.S. http://creativecommons.org/licenses/by-nc/3.0/us/

Keywords

antimicrobial peptides, MRSA, lysostaphin, skin infection, mice

Date of this Version

10-2014

DOI

10.2147/DDDT.S72129

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