Abstract
Osteoarthritis is a debilitating disease that results in pain and joint stiffness. Currently, steroidal and nonsteroidal anti-inflammatory drugs and supplements aimed at restoring lubrication to the affected joint are the most successful with respect to improving patient comfort. Due to the success in lubricating therapies, there exists a keen interest to develop better therapies that mimic how lubrication occurs naturally in the joint. Here we describe the results obtained using a chondroitin sulfate chain to which is conjugated peptides that bind to either hyaluronic acid (found in high concentrations in the synovial fluid) or collagen type II (present on the cartilage surface). Our study investigates the effect of binding to the cartilage surface and interacting with hyaluronic acid on lubrication at the cartilage surface. The results described here suggest that binding to the cartilage surface is critical to supporting lubrication and did not require the addition of hyaluronic acid to reduce friction.
Keywords
lubrication, cartilage, osteoarthritis, friction, lubricin, hyaluronic acid
Date of this Version
3-27-2020
Recommended Citation
Twitchell, Celina; Walimbe, Tanaya; Liu, Julie C.; and Panitch, Alyssa, "Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface" (2020). School of Chemical Engineering Faculty Publications. Paper 15.
https://docs.lib.purdue.edu/chepubs/15
Comments
This is the publisher PDF of Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface; Julie C. Liu; Current Research in Biotechnology; Volume 2, November 2020, Pages 16-21. Published CC-BY-NC-ND by Elsevier, the version of record and ADA Title II compliant version is available in HTML at DOI 10.1016/j.crbiot.2020.02.002.