Abstract
Here, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes. Treatment of these disks and domes with metal ions such as Fe(II), Cu(II), Zn(II), Co(II), and Ru(III) triggered the formation of microcages, and micron-sized cup-like structures. Mechanistic studies suggest that the formation of the microcages proceeds from the disks and domes in a metal-dependent fashion. Fluorescently-labeled dextrans were encapsulated within the cages and displayed a time-dependent release using thermal conditions.
Keywords
Collagen mimetic peptide; hierarchical self-assembly; encapsulation; thermal release
Date of this Version
8-12-2021
DOI
10.3390/molecules26164888
Recommended Citation
Gleaton, J.; Curtis, R.W.; Chmielewski, J. Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions. Molecules 2021, 26, 4888. https://doi.org/10.3390/molecules26164888
Comments
This article is published under a CC-BY license.
Gleaton, J.; Curtis, R.W.; Chmielewski, J. Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions. Molecules 2021, 26, 4888. https://doi.org/10.3390/molecules26164888