A circulatory arrest model in the rat was developed for use in cerebral and cardiac resuscitation studies. Whole-body ischemia was produced for 8 to 18 minutes by arresting the heart with a cold potassium chloride cardioplegic solution. Following cardiopulmonary resuscitation, minimal, standardized intensive care was provided. As the duration of ischemia was increased from 8 to 18 minutes, survival immediately following resuscitation decreased from 100% to 25%, and survival at 48 hours after ischemia decreased from 80% to 0%. Thirty per cent of the rats recovering from 11 minutes of ischemia suffered motor seizures. Survival and the incidence of motor seizures appear to be good measures of outcome following ischemic circulatory arrest. These measures can be used to test the possible anti-ischemic actions of calcium antagonists or other drugs.
animal model, calcium antagonists, cardiac arrest, cerebral ischemia, CPR, long term survival, potassium-induced arrest
Date of this Version
De Garavilla, Lawrence; Babbs, Charles F.; and Tacker, Willis A., "An Experimental Circulatory Arrest Model in the Rat to Evaluate Calcium Antagonists in Cerebral Resuscitation" (1984). Weldon School of Biomedical Engineering Faculty Publications. Paper 85.