Abstract
Effects of antiarrhythmic drugs upon the threshold delivered energy (TDE) and threshold peak current (TPC) for electrical ventricular defibrillation by damped sinusoidal shocks were investigated in 25 pentobarbital-anesthetized dogs. TDE and TPC were increased by the three antiarrhythmic drugs tested. Bolus injections produced a transient rise, and continuous infusions produced a steady rise in defibrillation threshold. The maximal percent elevations in mean defibrillation threshold during the 60 minutes after intravenous drug treatment in groups of n = 5 dogs were: Treatment % increase in TDE % increase in TPC Lidocaine bolus (3 mg/kg) 48 26 Lidocaine (0.5 mg/Kg/min) 99 45 Quinidine bolus (50 mg/Kg) 172 70 Diphenylhydantoin (1 mg/Kg/min) 83 35 Controls 1 4 Accordingly, individuals receiving antiarrhythmic drugs whose hearts nonetheless fibrillate may require greater electric shock strength for defibrillation.
Keywords
ACLS, advanced cardiac life support, cardiac arrest, fibrillation, resuscitation
Date of this Version
1979
Recommended Citation
Babbs, Charles F.; Yim, GKW; Whistler, S J.; Tacker, W A.; and Geddes, L A., "Elevation of ventricular defibrillation threshold in dogs by antiarrhythmic drugs" (1979). Weldon School of Biomedical Engineering Faculty Publications. Paper 45.
https://docs.lib.purdue.edu/bmepubs/45
Comments
This is the author accepted manuscript of Babbs C.F., Yim G.K.W., Whistler S.J., Tacker W.A., Geddes L.A., Elevation of ventricular defibrillation threshold in dogs by antiarrhythmic drugs, American Heart Journal 98, 345-350, 1979. Copyright Elsevier, it is made available here CC-BY-NC-ND, and the version of record is available at http://dx.doi.org/10.1016/0002-8703(79)90047-4.