Successful cancer therapy must selectively destroy tumor tissue while sparing the host's normal tissues. Local heat treatment can have such a selective effect because abnormalities in tumor blood vessels supply less oxygen to heat-stressed tumor cells and are less efficient in cooling tumor tissue by blood perfusion.
cancer, treatment of; heat therapy; hydralazine; hyperthermia; vasodilators; tumors
Date of this Version
Babbs, Charles F., "Biology of local heat therapy for cancer" (1982). Weldon School of Biomedical Engineering Faculty Publications. Paper 124.