Human intracranial tumours were treated using local heat therapy produced by surgically implanted catheters containing local resistive heating elements. Changes in local tumor blood flow were assessed indirectly from an algorithm based on the bioheat transfer equation. The algorithm used the ratio of catheter power to catheter temperature rise to estimate regional blood perfusion. Local heat therapy produced consistent reductions in local apparent perfusion. Changes in apparent regional perfusion occurred in intriguing patterns that gave clues to possible vascular events of therapeutic significance.


This is the author accepted manuscript version of Patel U.H., Babbs C.F., DeFord J.A., Bleyer M.W., Marchosky J.A., Moran C.J., Evidence of changes in regional blood perfusion in human intracranial tumours during conductive interstitial hyperthermia, Med. Biol. Eng. Comp. 30, 651-655, 1992. Copyright Springer, the version of record is available at http://dx.doi.org/10.1007/BF02446799.


Bioheat transfer equation, Conductive heating Interstitial hyperthermia, Tumour blood flow

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