Presenter Information

Jiada ZhanFollow

Keywords

magnesium bioavailability, ionized magnesium, picometer-sized, human study

Select the category the research project fits.

Life Sciences

Is this submission part of ICaP/PW (Introductory Composition at Purdue/Professional Writing)?

No

Abstract

Magnesium is an essential nutrient for the human body. However, half of the United States (US) population fails to consume an adequate amount of magnesium from foods. Moreover, magnesium status in the US population could be compromised by certain chronic diseases and medications. Taking dietary supplements containing magnesium significantly increased the magnesium intake of the US population. Scientists have speculated that reducing the ion size of mineral salts, can improve their bioavailability. Nevertheless, there is no known human study that compares the bioavailability of two different ionic size magnesium salts. Also, few studies assessed the blood concentration of ionized magnesium (iMg), but iMg was thought to be the active form of magnesium. Therefore, the rationale of this study was to address the gap in the literature by comparing the magnesium bioavailability between two magnesium supplements: ReMag (picometer-sized magnesium chloride) and Natural Vitality Calm (normal-sized magnesium citrate) using the blood iMg total Area Under the Curve (total AUC), the maximum concentration of blood iMg (Cmax) and the time to reach the maximum concentration of blood iMg (Tmax). We conducted a preliminary analysis of 5 participants by performing paired sample t-tests. The results showed that over 24 hours following administration of supplements, no differences were found between ReMag and Natural Vitality Calm for blood iMg, Cmax and Tmax. Our findings did not support our hypothesis that ReMag would be more bioavailable and be absorbed faster.

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Compare the bioavailability of two different-sized of magnesium supplements

Magnesium is an essential nutrient for the human body. However, half of the United States (US) population fails to consume an adequate amount of magnesium from foods. Moreover, magnesium status in the US population could be compromised by certain chronic diseases and medications. Taking dietary supplements containing magnesium significantly increased the magnesium intake of the US population. Scientists have speculated that reducing the ion size of mineral salts, can improve their bioavailability. Nevertheless, there is no known human study that compares the bioavailability of two different ionic size magnesium salts. Also, few studies assessed the blood concentration of ionized magnesium (iMg), but iMg was thought to be the active form of magnesium. Therefore, the rationale of this study was to address the gap in the literature by comparing the magnesium bioavailability between two magnesium supplements: ReMag (picometer-sized magnesium chloride) and Natural Vitality Calm (normal-sized magnesium citrate) using the blood iMg total Area Under the Curve (total AUC), the maximum concentration of blood iMg (Cmax) and the time to reach the maximum concentration of blood iMg (Tmax). We conducted a preliminary analysis of 5 participants by performing paired sample t-tests. The results showed that over 24 hours following administration of supplements, no differences were found between ReMag and Natural Vitality Calm for blood iMg, Cmax and Tmax. Our findings did not support our hypothesis that ReMag would be more bioavailable and be absorbed faster.