Date of Award
Summer 2014
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Jean A. Chmielewsky
Committee Chair
Jean A. Chmielewsky
Committee Member 1
Arun K. Ghosh
Committee Member 2
Christine A. Hyrcyna
Abstract
Antimicrobial resistance has been an exponentially growing problem since the discovery of antibiotics. Antibiotics have been misused for many years and this misuse has grown into a real problem for the medical community. While there are countless safeguards to prevent infection by a resistant strain of bacteria, there are still many plagued by it and must be treated with sometimes dangerous antibiotics. Melittin, along with many other peptides, contain potent antimicrobial properties, but are also toxic toward enthrocytes. The control of the secondary structure of peptides provides the key to adjusting their activity.
Recommended Citation
Molinets, Zachary B., "Investigation into the control of melittin secondary structure and antimicrobial activity" (2014). Open Access Theses. 656.
https://docs.lib.purdue.edu/open_access_theses/656
Included in
Analytical Chemistry Commons, Biochemistry Commons, Medicine and Health Sciences Commons, Pharmacology Commons