Date of Award
8-2018
Degree Type
Thesis
Degree Name
Master of Science (MS)
Department
Biological Science
Committee Chair
Edward Bartlett
Committee Member 1
Amy Brewster
Committee Member 2
Scott Pluta
Abstract
Status Epilepticus has been shown to increase the risk of developing epilepsy later in life. Anatomical changes such as dendritic instability and reduction in neurotransmitter associated vesicles have been found within the hippocampus. In this study, local field potential recordings in hippocampal slices were measured to determine how the anatomical variation between control and status epilepticus induced animals correlated to function changes in synaptic efficacy and plasticity. Rats and mice induced with status epilepticus were found to have decreased synaptic efficacy, but appeared to demonstrate varying plasticity compensation at different stimulation intensities.
Recommended Citation
Sommer, Alexandra L., "Physiological Changes in Hippocampal CA3-CA1 Network Following Pilocarpine Induced Status Epilepticus" (2018). Open Access Theses. 1597.
https://docs.lib.purdue.edu/open_access_theses/1597