Date of Award

January 2015

Degree Type


Degree Name

Doctor of Philosophy (PhD)


Pharmacy Practice

First Advisor

Joseph Thomas III

Committee Member 1

Mark Moriarty

Committee Member 2

Michael Murray

Committee Member 3

Mangala Subramaniam


The objectives of this study were to determine prevalence of sickle cell disease (SCD) in a Medicaid population, to determine all-cause health care resource utilization and incremental health care resource utilization associated with SCD. An observational database analysis was conducted using information from a large administrative claims database. Individuals continuously enrolled in a tracked health plan during the period from January 1, 2012 through December 31, 2012, were eligible for inclusion in the sample for determination of SCD prevalence. To select the sample for estimating all-cause resource utilization and incremental resource utilization associated with SCD, administrative claims and enrollment records from January 1, 2012 through December 31, 2012 were examined to select 8,652 individuals with SCD based on ICD-9-CM diagnosis codes. SCD patients were linked one-to-one on age, gender, and race with individuals without SCD resulting in 8,652 persons in the comparison group and a total of 17,304 persons in the overall sample.