Date of Award
January 2015
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Medicinal Chemistry and Molecular Pharmacology
First Advisor
Markus A Lill
Second Advisor
Elizabeth M Topp
Committee Member 1
Carol B Post
Committee Member 2
Chiwook Park
Committee Member 3
Daisuke Kihara
Abstract
A computational method to model the steric zipper of amyloid fibrils (FibPreditor) is developed. The method generates an ensemble of structures for the steric zipper by a number of geometric operations and presents the most energetically favorable candidates as models of steric zipper. The method is shown to successfully reproduce a number of experimentally determined fibril structures.
Recommended Citation
Tabatabaei Ghomi, Hamed, "COMPUTATIONAL MODELLING OF PROTEIN FIBRILLATION WITH APPLICATION TO GLUCAGON" (2015). Open Access Dissertations. 1321.
https://docs.lib.purdue.edu/open_access_dissertations/1321