Date of Award

January 2016

Degree Type


Degree Name

Doctor of Philosophy (PhD)


Chemical Engineering

First Advisor

Zoltan K Nagy

Committee Member 1

Gintaras V Reklaitis

Committee Member 2

Michael T Harris

Committee Member 3

Christopher L Burcham

Committee Member 4

James D Litster


Crystallization is an important separation and purification technique for a wide variety of solid products in pharmaceutical, food and fine chemical industries. The production of more than 90% of the active pharmaceutical ingredients (APIs) involves crystallization. Therefore, it is crucial to design and control pharmaceutical crystallization processes so that the desired process requirement and product critical quality attributes (CQAs), including process yield, crystal purity, crystal size distribution (CSD), crystal shape and polymorphic form can be obtained. Studies about cooling or antisolvent only batch crystallization of pure APIs have been extensively reported in the literature in the last century. But design and control of more complex and integrated crystallization operation and systems require further development to meet the needs of improved CQAs, simplified process design and automated process control in pharmaceutical manufacturing.