Date of Award

January 2016

Degree Type


Degree Name

Doctor of Philosophy (PhD)


Comparative Pathobiology

First Advisor

Mohamed Seleem

Committee Member 1

Yoon Yeo

Committee Member 2

Lynn F Guptill-Yoran

Committee Member 3

Ramesh Vemulapalli


The emergence of antibiotic resistance is a notorious problem worldwide. In the United States alone, antibiotic-resistant bacteria infect at least two million people and kill around 23,000 patients each year. Half of these infections are attributed to the bacterial pathogen, methicillin resistant Staphylococcus aureus (MRSA) according to a report published in 2013 by the Centers for Disease Control and Prevention (CDC). Similarly, S. pseudintermedius is a leading cause of opportunistic infections in pet animals and has zoonotic potential. Furthermore, the marked increase in the incidence of infections due to extensively drug-resistant and pandrug-resistant isolates of Pseudomonas aeruginosa and Acinetobacter baumannii presents an alarming challenge that necessitates the development of novel therapeutic alternatives to traditional antibiotics in order to address this scourge.