Date of Award

January 2016

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Computer Science

First Advisor

DAISUKE KIHARA

Committee Member 1

ALEX POTHEN

Committee Member 2

JENNIFER NEVILLE

Committee Member 3

KIHONG PARK

Committee Member 4

ROBERT D. SKEEL

Abstract

Functional annotations of novel or unknown proteins is one of the central problems in post-genomics bioinformatics research. With the vast expansion of genomic and proteomic data and technologies over the last decade, development of automated function prediction (AFP) methods for large-scale identification of protein function has be-come imperative in many aspects. In this research, we address two important divergences from the “one protein – one function” concept on which all existing AFP methods are developed:

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