Date of Award

January 2016

Degree Type


Degree Name

Doctor of Philosophy (PhD)



First Advisor

Garth J Simpson

Committee Member 1

Mary J Wirth

Committee Member 2

Chittaranjan Das

Committee Member 3

Lynne S Taylor


The crystalline form of a solid can profoundly affect its physical and chemical properties, with both potentially stable and metastable crystal polymorphs are accessible during crystal formation. Conventional methods limit the detection of rare nucleation and rapid phase transitioning events due to their lack of selectivity and sensitivity. Inkjet printing of a solution confines the nucleation event in a few micrometer volumes within the droplet, and furthermore rapid desolvation favors the kinetic factor to trap the rare metastable polymorphs. Second harmonic generation microscopy (SHG) possesses enough sensitivity to detect sub-micrometer size chiral crystals selectively and has the potential for use in crystal nucleation studies.