Date of Award
Doctor of Philosophy (PhD)
Medicinal Chemistry and Molecular Pharmacology
Committee Member 1
Committee Member 2
Committee Member 3
Chronic Myelogenous Leukemia (CML) is a hematopoietic cancer caused by the formation of the Philadelphia chromosome, a reciprocal translocation of the ABL1 oncogene on chromosome 9, and the breakpoint cluster region gene (BCR) chromosome 22, resulting in the BCR-ABL oncoprotein. BCR-ABL is a constitutively active tyrosine kinase that regulates cell growth and differentiation, leading to uncontrolled cell proliferation by deregulating downstream signaling pathways.
Noel, Brett, "Proteogenomic Insights Into The Nature Of Chemoresistance In Chronic Myelogenous Leukemia" (2015). Open Access Dissertations. 1136.