Date of Award

January 2015

Degree Type


Degree Name

Doctor of Philosophy (PhD)


Biomedical Engineering

First Advisor

Ouyang Zheng

Committee Member 1

Edward Bartlett

Committee Member 2

Eugenio Culurciello

Committee Member 3

R.Gram Cooks


Mass spectrometry has been actively involved in the areas of healthcare, pharmaceutics, environmental analysis, food industry and forensics due to its ability to provide molecular information at trace levels. Recently, because of the complexity of chemical and biological samples, computer-assisted mass spectra analysis, including signal enhancement, statistics and machine learning, has been drawn more and more attention especially for researches in biomarker identification, sample classification and omics-related areas where high volume of data is generated.