Nanoparticles for multimodal in vivo imaging in nanomedicine

Jaehong Key, Purdue University, Birck Nanotechnology Center
James F. Leary, Purdue University, Birck Nanotechnology Center

Date of this Version



This is the Publisher PDF of Key, J and Leary, JF. "Nanoparticles for multimodal in vivo imaging in nnomedicine." International Journal of Nanomedicine, 9(1):711-726. 2014. Published by Dove Press, it is made available here with a CC-BY-NC license and is also available at


While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously provide diagnostic information by a variety of in vivo imaging methods. These diagnostic capabilities make use of specific properties of nanoparticle core materials. Near-infrared fluorescent probes provide optical detection of cells targeted by real-time nanoparticle-distribution studies within the organ compartments of live, anesthetized animals. By combining different imaging modalities, we can start with deep-body imaging by magnetic resonance imaging or computed tomography, and by using optical imaging, get down to the resolution required for real-time fluorescence-guided surgery.


Nanoscience and Nanotechnology