Atomic force microscopy-coupled microcoils for cellular-scale nuclear magnetic resonance spectroscopy

Charilaos Mousoulis, Birck Nanotechnology Center, Purdue University
Teimour Maleki, Birck Nanotechnology Center, Purdue University
Babak Ziaie, Birck Nanotechnology Center, Purdue University
Corey Neu, Birck Nanotechnology Center, Purdue University

Date of this Version



Copyright (2013) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Appl. Phys. Lett. 102, 143702 (2013) and may be found at The following article has been submitted to/accepted by Applied Physics Letters. Copyright (2013) Charilaos Mousoulis, Teimour Maleki, Babak Ziaie and Corey P. Neu. This article is distributed under a Creative Commons Attribution 3.0 Unported License


We present the coupling of atomic force microscopy (AFM) and nuclear magnetic resonance (NMR) technologies to enable topographical, mechanical, and chemical profiling of biological samples. Here, we fabricate and perform proof-of-concept testing of radiofrequency planar microcoils on commercial AFM cantilevers. The sensitive region of the coil was estimated to cover an approximate volume of 19.4 x 10(3) mu m(3) (19.4 pl). Functionality of the spectroscopic module of the prototype device is illustrated through the detection of H-1 resonance in deionized water. The acquired spectra depict combined NMR capability with AFM that may ultimately enable biophysical and biochemical studies at the single cell level. (C) 2013 AIP Publishing LLC


Nanoscience and Nanotechnology