Biodegradable Microfabricated Plug-Filters for Glaucoma Drainage Devices

Teimour Maleki, Birck Nanotechnology Center, Purdue University
Girish Chitnis, Birck Nanotechnology Center, Purdue University
Jun Hyeong Park, Birck Nanotechnology Center, Purdue University
Louis B. Cantor, Indiana University-Purdue University Indianapolis
Babak Ziaie, Birck Nanotechnology Center, Purdue University

Abstract

We report on the development of a batch fabricated biodegradable truncated-cone-shaped plug filter to overcome the postoperative hypotony in nonvalved glaucoma drainage devices. Plug filters are composed of biodegradable polymers that disappear once wound healing and bleb formation has progressed past the stage where hypotony from overfiltration may cause complications in the human eye. The biodegradable nature of device eliminates the risks associated with permanent valves that may become blocked or influence the aqueous fluid flow rate in the long term. The plug-filter geometry simplifies its integration with commercial shunts. Aqueous humor outflow regulation is achieved by controlling the diameter of a laser-drilled through-hole. The batch compatible fabrication involves a modified SU-8 molding to achieve truncated-cone-shaped pillars, polydimethylsiloxane micromolding, and hot embossing of biodegradable polymers. The developed plug filter is 500 mu m long with base and apex plane diameters of 500 and 300 mu m, respectively, and incorporates a laser-drilled through-hole with 44-mu m effective diameter in the center.

Discipline(s)

Nanoscience and Nanotechnology