The Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University provides knowledge on basic chemical and biological sciences for the improvement of human health.

This series contains publications from the Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University.

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Submissions from 2020

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Aprepitant, An Antiemetic Agent, Interferes with Metal Ion Homeostasis of Candida Auris and Displays Potent Synergistic Interactions With Azole Drugs, Hassan E. Eldesouky, Nadia A. Lanman, Tony Hazbun, and Mohamed N. Seleem

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Ospemifene Displays Broad-Spectrum Synergistic Interactions with Itraconazole Through Potent Interference with Fungal Efflux Activities, Hassan E. Eldesouky, Ehab A. Salama, Tony R. Hazbun, Abdelrahman S. Mayhoub, and Mohamed N. Seleem

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Repurposing Approach IdentifiesPitavastatin as a Potent AzoleChemosensitizing Agent EffectiveAgainst Azole-Resistant CandidaSpecies, Hassan E. Eldesouky, Ehab A. Salama, Xiaoyan Li, Tony R. Hazbun, Abdelrahman S. Mayhoub, and Mohamed N. Seleem

Submissions from 2019

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Inferring Gene RegulatoryNetworks from a Populationof Yeast Segregants, Chen Chen, Tony R. Hazbun, and Min Zhang

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Antibiotic-induced Decreases inthe Levels of Microbial-derivedShort-chain Fatty Acids Correlatewith Increased GastrointestinalColonization of Candida Albicans, Jack Guinan, Shaohua Wang, Tony R. Hazbun, Hariom Yadav, and Shankar Thangamani

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Identification of a PhenylthiazoleSmall Molecule with DualAntifungal and Antibiofilm ActivityAgainst Candida albicans andCandida auris, Haroon Mohammad, Hassan E. Eldesouky, Tony R. Hazbun, Abdelrahman S. Mayhoub, and Mohamed N. Seleem

Submissions from 2017

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Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway, Shankar Thangamani, Matthew Maland, Haroon Mohammad, Pete E. Pascuzzi, Larisa Avramova, Carla E. Koehler, Tony R. Hazbun, and Mohamed N. Seleem

Submissions from 2015

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Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease, Soumira Ghosh and Robert Geahlen

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Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius, Haroon Mohammad, P.V. N. Reddy, Dennis Monteleone, Abdelrahman S. Mayhoub, Mark S. Cushman, G. Kenitra Hammac, and Mohamed N. Seleem

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The Mps1 Kinase Modulates the Recruitment and Activity of Cnn1CENP-T at Saccharomyces cerevisiae Kinetochores, Kriti Shrestha Thapa, Amanda Oldani, Cinzia Pagliuca, Peter De Wulf, and Tony R. Hazbun

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Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process, Chai-Jui Tsai, Kiran Aslam, Holli M. Drendel, Josephat M. Asiago, Kourtney M. Goode, Lake N. Paul, Jean-Christophe Rochet, and Tony R. Hazbun

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Reversible linkage of two distinct small molecule inhibitors of myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines, Jutta Wanner, Darlene Romashko, Douglas S. Werner, Earl W. May, Yue Peng, Ryan Schulz, Kenneth W. Foreman, Suzanne Russo, Lee D. Arnold, Maneesh R. Pingle, Donald E. Bergstrom, Francis Barany, and Stuart Thomson

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The Antitumorigenic Function of EGFR in Metastatic Breast Cancer is Regulated by Expression of Mig6, Michael Wendt, Whitney K. Williams, Pete E. Pascuzzi, Nikolas G. Balanis, Barbara J. Schiemann, Cathleen R. Carlin, and William P. Schiemann

Submissions from 2014

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PharmDock: A Pharmacophore-Based Docking Program, Bingjie Hu and Markus A. Lill

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IterTunnel; a Method for Predicting and Evaluating Ligand EgressTunnels in Proteins with Buried Active Sites, Laura J. Kingsley and Markus A. Lill

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A Genome-Wide Association Study Identifies a Locus on TERT for Mean Telomere Length in Han Chinese., Yun Liu, Lan Cao, Zhiqiang Li, Daizhan Zhou, Wanqing Liu, Qin Shen, Yanting Wu, Dan Zhang, Xun Hu, Ting Wang, Junyi Ye, Xiaoling Weng, Hong Zhang, Di Zhang, Zhou Zhang, Fatao Liu, Lin He, and Yongyong Shi

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Fibroblast Growth Factor Receptor Splice Variants are Stable Markers of Oncogenic Transforming Growth Factor β1 Signaling in Metastatic Breast Cancers., Michael K. Wendt, Molly A. Taylor, Barbara J. Schiemann, Khalid Sossey-Alaoui, and William P. Schiemann

Submissions from 2013

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Elevated Phospholipase A2 Activities in Plasma Samples from Multiple Cancers., Hui Cai, Elena G. Chiorean, Michael V. Chiorean, Douglas K. Rex, Bruce W. Robb, Noah M. Hahn, Ziyue Liu, Patrick J. Loehrer, Marietta L. Harrison, and Yan Xu

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Solvent Dependency of the UV-Vis Spectrum of Indenoisoquinolines: Role of Keto-Oxygens as Polarity Interaction Probes., Andrea Coletta, Silvia Castelli, Giovanni Chillemi, Nico Sanna, Mark S. Cushman, Yves Pommier, and Alessandro Desideri

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Epigenetic Regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA Methylation and Histone Modification., Baisheng Fu, Hongwei Wang, Jinhua Wang, Ivana Barouhas, Wanqing Liu, Adam Shuboy, David A. Bushinsky, Dongsheng Zhou, and Murray J. Favus

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Synthesis and Biological Evaluation of Novel Folic Acid Receptor-Targeted, β-Cyclodextrin-Based Drug Complexes for Cancer Treatment., Juan-Juan Yin, Sonali Sharma, Stepan P. Shumyak, Zhi-Xin Wang, Zhi-Wei Zhou, Yangde Zhang, Peixuan Guo, Chen-Zhong Li, Jagat R. Kanwar, Tianxin Yang, Shyam S. Mohapatra, Wanqing Liu, Wei Duan, Jian-Cheng Wang, Qi Li, Xueji Zhang, Jun Tan, Lee Jia, Jun Liang, Ming Q. Wei, Xiaotian Li, and Shu-Feng Zhou

Submissions from 2012

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Portable Bacterial Identification System Based on Elastic Light Scatter Patterns, Euiwon Bae, Dawei Ying, Donald Kramer, Valery Patsekin, Bartek Rajwa, Cheryl Holdman, Jennifer Sturgis, Vincent J. Davisson, and J Paul Robinson

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Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction., Giordano Mancini, Ilda D'Annessa, Andrea Coletta, Giovanni Chillemi, Yves Pommier, Mark S. Cushman, and Alessandro Desideri

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Anti-Malarial Activity of Geldanamycin Derivatives in Mice Infected with Plasmodium yoelii, Rubul Mout, Zhi-Dong Xu, Angela KH Wolf, Vincent J. Davisson, and Gotam K. Jarori

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Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic Cancer, Bing Song, X Shawn Liu, Steven J. Rice, Shihuan Kuang, Bennett D. Elzey, Stephen F. Konieczny, Timoty L. Ratliff, Tony R. Hazbun, Elena G. Chiorean, and Xiaoqi Liu

Submissions from 2011

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A Synergistic Antiproliferation Effect of Curcumin and Docosahexaenoic Acid in SK-BR-3 Breast Cancer Cells: Unique Signaling Not Explained by the Effects of Either Compound Alone., Jeffrey D. Altenburg, Andrew A. Bieberich, Colin Terry, Kevin A. Harvey, Justin F. VanHorn, Zhidong Xu, Vincent J. Davisson, and Rafat A. Siddiqui

Submissions from 2009

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Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR., Sean Ekins, Sandhya Kortagere, Manisha Iyer, Erica J. Reschly, Markus A. Lill, Matthew R. Redinbo, and Matthew D. Krasowski

Submissions from 2007

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A Protein Interaction Map of the Mitotic Spindle, Jonathan Wong, Yuko Nakajima, Stefan Westermann, Ching Shang, Jung-Seog Kang, Crystal Goodner, Pantea Houshmand, Stanley Fields, Clarence S.M. Chan, David Drubin, Georjana Barnes, and Tony R. Hazbun

Submissions from 2003

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Riboflavin Synthase of Schizosaccharomyces pombe. Protein Dynamics Revealed by 19F NMR Protein Perturbation Experiments., Markus Fischer, Ann-Kathrin Schott, Kristina Kemter, Richard Feicht, Gerald Richter, Boris Illarionov, Wolfgang Eisenreich, Stefan Gerhardt, Mark S. Cushman, Stefan Steinbacher, Robert Huber, and Adelbert Bacher