Foods and Nutrition
calcium, genetics, diet, bone, mouse
Both dietary calcium and genetics influence bone density and structure. However, how genetics
affect the adaptation response of bone parameters to dietary calcium (Ca) restriction is unknown.
11 inbred strains of mice were fed adequate (0.5%) or low (0.25%) Ca diets from 4-12 weeks of
age and were evaluated for gene-by-diet interactions affecting bone structure at the femur and
lumbar spine. We observed that genetics and diet main effects as well as gene-by-diet
interactions significantly affected femur trabecular and cortical bone, and lumbar spine
trabecular bone microCT parameters. There were no significant correlations between basal and
adaptation parameters in femur or lumbar spine. Adaptation of lumbar spine trabecular bone
parameters was smaller compared to adaptation observed in the femur trabecular bone. However,
the adaptation parameters in these two bone sites were significantly and positively correlated.
We conclude that (1) genetic controls of basal and adaptive bone parameters are distinct; (2)
trabecular bone in lumbar spine is more resistant to calcium restriction than the trabecular bone
in distal femur; (3) similar genetic forces affect the adaptation response in distal femur and
lumbar spine trabecular bone. However, site-specific regulation may exist in bone structure
adaptation response to calcium restriction in some of the inbred lines.
Lan, Xu, "Genetic Differences Control the Response of Femur and Lumbar Spine Trabecular Bone Microstructure to Dietary Calcium Restriction in Mice" (2013). College of Health and Human Sciences Honors Program Undergraduate Theses. 18.