Recommended Citation
Vivas-Valencia, C., Zhou, Y., Sai, A. et al. A two-phase approach to re-calibrating expensive computer simulation for sex-specific colorectal neoplasia development modeling. BMC Med Inform Decis Mak 22, 244 (2022). https://doi.org/10.1186/s12911-022-01991-7
DOI
10.1186/s12911-022-01991-7
Date of this Version
9-18-2022
Keywords
Computationally expensive simulator, colorectal neoplasia, state- transition model, model recalibration
Abstract
Medical evidence from more recent observational studies may significantly alter our understanding of disease incidence and progression, and would require recalibration of existing computational and predictive disease models. However, it is often challenging to perform recalibration when there are a large number of model parameters to be estimated. Moreover, comparing the fitting performances of candidate parameter designs can be difficult due to significant variation in simulated outcomes under limited computational budget and long runtime, even for one simulation replication.
Comments
This is the publisher's version of Vivas-Valencia, C., Zhou, Y., Sai, A. et al. A two-phase approach to re-calibrating expensive computer simulation for sex-specific colorectal neoplasia development modeling. BMC Med Inform Decis Mak 22, 244 (2022). https://doi.org/10.1186/s12911-022-01991-7