Recommended Citation
Wang, Weidong; Chen, Liyang; Fengler, Kevin; Bolar, Joy; Llaca, Victor; Wang, Xutong; Clark, Chancelor B.; Fleury, Tomara J.; Myrvold, Jon; Oneal, David; van Dyk, Maria Magdalena; Hudson, Ashley; Munkvold, Jesse; Baumgarten, Andy; Thompson, Jeff; Cai, Guohong; Crasta, Oswald; Aggarwal, Rajat; and Ma, Jianxin, "A giant NLR gene confers broad-spectrum resistance to Phytophthora sojae in soybean" (2021). Purdue University Libraries Open Access Publishing Fund. Paper 162.
http://dx.doi.org/10.1038/s41467-021-26554-8
DOI
10.1038/s41467-021-26554-8
Date of this Version
11-5-2021
Abstract
Phytophthora root and stem rot caused by P. sojae is a destructive soybean soil-borne disease found worldwide. Discovery of genes conferring broad-spectrum resistance to the pathogen is a need to prevent the outbreak of the disease. Here, we show that soybean Rps11 is a 27.7-kb nucleotide-binding site-leucine-rich repeat (NBS-LRR or NLR) gene conferring broad-spectrum resistance to the pathogen. Rps11 is located in a genomic region harboring a cluster of large NLR genes of a single origin in soybean, and is derived from rounds of unequal recombination. Such events result in promoter fusion and LRR expansion that may contribute to the broad resistance spectrum. The NLR gene cluster exhibits drastic structural diversification among phylogenetically representative varieties, including gene copy number variation ranging from five to 23 copies, and absence of allelic copies of Rps11 in any of the non-Rps11-donor varieties examined, exemplifying innovative evolution of NLR genes and NLR gene clusters.
Comments
This is the publisher PDF of Wang, W., Chen, L., Fengler, K. et al. A giant NLR gene confers broad-spectrum resistance to Phytophthora sojae in soybean. Nature Communications 12, 6263 (2021). This article is distributed under a CC-BY license, and is available at DOI: 10.1038/s41467-021-26554-8.