Recommended Citation
Henderson, Gregory C.; Martinez Tenorio, Valeria; and Tuazon, Marc A., "Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner" (2020). Purdue University Libraries Open Access Publishing Fund. Paper 141.
http://dx.doi.org/10.1186/s12944-020-01395-4
DOI
10.1186/s12944-020-01395-4
Date of this Version
10-8-2020
Keywords
Lipidomics, High-intensity interval training, Postexercise recovery, Post-exercise, Intrahepatocellular lipid, Triglyceride
Abstract
Background
The content of triacylglycerol (TAG) in the liver is known to rapidly increase after a single bout of exercise followed by recovery to sedentary levels. The response of other hepatic lipids, and acyl chain composition of lipid classes, would provide a deeper understanding of the response of hepatic lipid metabolism to acute exercise.
Methods
Female mice performed a single bout of continuous exercise (CE), high-intensity interval exercise (HIIE), or no exercise (CON). The total content of various lipids in the liver, and fatty acids within lipid classes, were measured in tissues collected 3 h after exercise (Day 1) and the day following exercise (Day 2).
Results
The total concentration of TAG rose on Day 1 after exercise (P < 0.05), with a greater elevation in HIIE than CE (P < 0.05), followed by a decline toward CON levels on Day 2. The total concentration of other measured lipid classes was not significantly altered by exercise. However, n-6 polyunsaturated fatty acid relative abundance in diacylglycerol (DAG) was increased by HIIE (P < 0.05). In CON liver, TAG content was positively correlated with DAG and phosphatidylethanolamine (P < 0.05), while these statistical associations were disrupted in exercised mice on Day 1.
Conclusions
The response of lipid metabolism to exercise involves the coordination of metabolism between various tissues, and the lipid metabolism response to acute exercise places a metabolic burden upon the liver. The present findings describe how the liver copes with this metabolic challenge. The flexibility of the TAG pool size in the liver, and other remodeling of the hepatic lipidome, may be fundamental components of the physiological response to intense exercise.
Comments
This is the publisher PDF of Henderson, G.C., Martinez Tenorio, V. & Tuazon, M.A. Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner. Lipids in Health and Disease 19, 219 (2020). This article is distributed under a CC-BY license, and is available at DOI: 10.1186/s12944-020-01395-4.