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This special issue addresses contemporary representations of “vulnerable” bodies in transit in Anglophone literature and culture and explores their strategies of resistance. The use of the expression “bodies in transit” in this issue has to be understood both as a reference to the materiality of diasporic, exiled, migrating, trafficked bodies, and as an allusion to the metaphorical transition of these marginalized subjects from alienation to regeneration in multiple contexts. The interdisciplinary contributions in this special issue tackle vulnerability as a marginal(ized) and potentially enabling condition entailing the crossing of bodily, sexual, mental, ethical, cultural, and national borders. Ranging from literature to cinema, theatre and media, the articles address literary and cultural representations of historical, as well as racial, medical, and neo-liberal violence, in order to explore individual and collective forms of resilience emerging from vulnerability and marginalization.