Title

Anti-Fouling Control of Plug-Flow Crystallization via Heating and Cooling Cycle

Abstract

Plug-fow crystallization (PFC) is a promising continuous pharmaceutical crystal- lization process but is prone to fouling due to uncontrolled crystallization on the reactor surface (encrustation). This results in operational issues such as (1) fow blockage, (2) increased thermal resistance, and (3) reduced supersaturation, and in turn leads to limited continuous operation and reduced crystal quality and yield. In this work, we introduce a model-based anti-fouling control (AFC) via spatial and temporal heating and cooling cycle.

Comments

This is the publishers version of Koswara, A., Nagy, Z. K. Anti-Fouling Control of Plug-Flow Crystallization via Heating and Cooling Cycle. IFAC PapersOnLine 2015, 48, 193. DOI: 10.1016/j.ifacol.2015.08.180

Keywords

Spatio-temporal control, process control, model-based control, dynamic modeling, Ddnamic optimization, continuous crystallization, plug flow, fouling.

Date of this Version

9-25-2015

DOI

10.1016/j.ifacol.2015.08.180

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