Abstract
Background
It has long been recognized that sensitivity analysis plays a key role in modeling and analyzing cellular and biochemical processes. Systems biology markup language (SBML) has become a well-known platform for coding and sharing mathematical models of such processes. However, current SBML compatible software tools are limited in their ability to perform global sensitivity analyses of these models.
Results
This work introduces a freely downloadable, software package, SBML-SAT, which implements algorithms for simulation, steady state analysis, robustness analysis and local and global sensitivity analysis for SBML models. This software tool extends current capabilities through its execution of global sensitivity analyses using multi-parametric sensitivity analysis, partial rank correlation coefficient, SOBOL's method, and weighted average of local sensitivity analyses in addition to its ability to handle systems with discontinuous events and intuitive graphical user interface.
Conclusion
SBML-SAT provides the community of systems biologists a new tool for the analysis of their SBML models of biochemical and cellular processes.
Date of this Version
8-15-2008
DOI
10.1186/1471-2105-9-342
Recommended Citation
Zi, Zhike; Zheng, Yanan; Rundell, Ann E.; and Klipp, Edda, "SBML-SAT: a Systems Biology Markup Language (SBML) Based Sensitivity Analysis Tool" (2008). Weldon School of Biomedical Engineering Faculty Publications. Paper 16.
http://dx.doi.org/10.1186/1471-2105-9-342
Comments
This is the publisher pdf of Zhike Zi, Yanan Zheng, Ann E Rundell, Edda Klipp. SBML-SAT: a Systems Biology Markup Language (SBML) Based Sensitivity Analysis Tool. BMC Bioinformatics 2008, 9:342 (15 August 2008) and is available at: 10.1186/1471-2105-9-342.