Water is the support for life. Providing access to clean water has been identified as a grand challenge by the National Academy of Engineers. Water is associated with a variety of infectious diseases and public health. Infectious disease can be fatal for children, women, and elderly people. Our vision is to create technological innovation in detecting, preventing, and managing water-linked health and wellness issues that affect people’s lives. Based on SAWDIN framework (Sustainable Solution With Appropriate Technological Development and Innovation). We will achieve this goal via prioritized research, education, innovation, and entrepreneurial activities. Our initial global partner country is India and our partnering educational institution is Indian Institute of Technology – Kharagpur. Our targeted seed regions are two eastern States in India – Orissa and West Bengal. A bilateral workshop was hosted between Purdue University and India in March 2013 at IIT Kharagpur. In addition to the multidisciplinary faculty members and students from IIT Kharagpur and Purdue, other collaborating partners or contributors were from representatives from UNICEF India, a medical professional, representative from non-governmental organization (Water Initiative Orissa), and an irrigation engineer.