This symposium is a forum to present and discuss recent developments in the fundamental understanding of the relationship between performance of pharmaceutical oral solid dosage forms, manufacturing variables, and mechano-chemical properties of excipients and active ingredients. We invite presentations from experimental, numerical and modeling contributions to the field. Topics of interest include but are not limited to: crystal and particle engineering; stability and polymorphism; adhesion and bonding; feeding; blending; wet granulation; powder compaction; quality by design (QbD); destructive and nondestructive characterization of both powders and tablets; tablet disintegration and dissolution; and drug release.
Schedule

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A study on the sensitivity of Drucker–Prager cap model parameters during die compaction of pharmaceutical powders

Shrikant Swaminathan, Purdue University, United States
Carl Wassgren, Purdue University, United States

Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets

Juan Osorio, Purdue University, United States
Koushik Sowrirajan, FDA, United States
Fernando Muzzio, Rutgers University, United States

Feasibility study of terahertz time-domain measurement to monitor individual layer thickness of bilayer tablets

Yifan Wang, Rutgers University, United States
Fernando Muzzio, Rutgers University, United States
Alberto Cuitino, Rutgers University, United States
David Heaps, Advantest America, United States

Mechanical properties of powders for compaction and tableting: an overview

geamidon@med.umich.edu Gregory Amidon

NIR spectroscopy as a PAT tool for solid dosage continuous manufacturing

Krizia Karry, Rutgers University

Optimization of the breaking force and tensile strength relationship of doubly convex tablets under diametrical compression

Sonia Modarres Razavi, Rutgers University

Optimum drug dissolution time in an intermediate compression associated with different competing water penetration mechanisms

Gerardo Callegari, Rutgers University, United States
Sreenath Yeluri, Rutgers University, United States
Alberto Cuitino, Rutgers University, United States
German Drazer, Rutgers University, United States
Isamar Pastrana, University of Puerto Rico at Mayaguez, United States

PAT data management to enable advanced process monitoring and control on hot melt extrusion lines

Pamela Bruen Docherty, Siemens

Pharmaceutical and food surfaces of relevant composite materials and the characterization thereof

Teresa Carvajal, Purdue University, United States
Andrew Otte, Purdue University, United States
Dmitry Zemlyanov, Purdue University, United States
Rodolfo Pinal, Purdue University, United States

Predicting the degradation rate as a function of drug load in solid-state drug products

Steven Baertschi, Eli Lilly and Company, United States
Allison Dill, Eli Lilly and Company, United States
David Sperry, Eli Lilly and Company, United States
Timothy Kramer, Eli Lilly and Company, United States

Real-time particle dispersion from a DPI using image velocimetry – Evaluation of powder adhesion, impact, and collision

Xiang Kou, Purdue University – Novartis China
Andrew Otte, Purdue University, United States
Teresa Carvajal, Purdue University, United States
Steve Wereley, Purdue University, United States
Paul Heng, National University of Singapore, Singapore

Servohydraulic compaction simulators, an overview of the state-of-the-art

Jean LeFloch, Huxley Bertram

The role of particle size distribution on compaction and tensile strength of pharmaceutical powders

Bereket Yohannes, RUtgers University, United States
Alberto Cuitino, RUtgers University, United States
Marcial Gonzalez, Purdue University, United States
Admassu Abebe, Bristo-Myers Squibb, United States
Omar Sporckel, Bristo-Myers Squibb, United States
Faranak Nikfar, Bristo-Myers Squibb, United States
San Kiang, Bristo-Myers Squibb, United States

Towards continuous production of pharmaceutical cocrystals

Kevin Boksa, Purdue University, United States
Andrew Otte, Purdue University, United States
Rodolfo Pinal, Purdue University, United States