Synthetic materials usually suffer from a trade-off between stiffness and toughness. Many biological materials, on the other hand, show a unique blend of high strength and ductility. The combination of complex hierarchical geometry, material nonlinear response and special structural features provides mechanisms to resist fracture at multiple length scales leading to remarkable values of fracture toughness. This mini symposium welcomes contributions in the broader range of computational modeling and experimental characterization of multiscale toughness mechanisms in biomineralized tissues. Topics include but not limited to: 1) Physics of adhesion in biological tissues at microscale, 2) Multiscale modeling of crack propagation in biological materials, 3) experimental measurements of fracture properties at microscales, and 4) topology optimization of bio-mimetic materials.