Description
Traumatic brain injury (TBI), usually the result of impact or blast to the head, affects about 1.5 million Americans annually. Diffuse axonal injury, the hallmark feature of blunt TBI, has been investigated in direct mechanical loading conditions. However, recent evidence suggests inertial cavitation as a possible bTBI mechanism, particularly in the case of armed forces exposed to concussive blasts. Cavitation damage to free surfaces has been well-studied in the field of fluid dynamics, but bubble interactions within confined 3D environments have not been largely investigated. Cavitation occurs via a low-pressure region caused by pressure waves and is strongly dependent on local geometric and mechanical properties. The structural damage features as the result of cavitation – in particular at the cellular level – are incompletely understood, in part due to the rapid bubble formation and strain rates of up to ~105–106 s–1 . This project aims to characterize material damage in 2D and 3D environments and cell cultures by utilizing digital image correlation at a speed of up to ten 6 frames per second.
Recommended Citation
Estrada, J., & Franck, C. (2014). Microcavitation as a neuronal damage mechanism in blast -traumatic brain injury. In A. Bajaj, P. Zavattieri, M. Koslowski, & T. Siegmund (Eds.). Proceedings of the Society of Engineering Science 51st Annual Technical Meeting, October 1-3, 2014 , West Lafayette: Purdue University Libraries Scholarly Publishing Services, 2014. https://docs.lib.purdue.edu/ses2014/bio/mechano/5
Microcavitation as a neuronal damage mechanism in blast -traumatic brain injury
Traumatic brain injury (TBI), usually the result of impact or blast to the head, affects about 1.5 million Americans annually. Diffuse axonal injury, the hallmark feature of blunt TBI, has been investigated in direct mechanical loading conditions. However, recent evidence suggests inertial cavitation as a possible bTBI mechanism, particularly in the case of armed forces exposed to concussive blasts. Cavitation damage to free surfaces has been well-studied in the field of fluid dynamics, but bubble interactions within confined 3D environments have not been largely investigated. Cavitation occurs via a low-pressure region caused by pressure waves and is strongly dependent on local geometric and mechanical properties. The structural damage features as the result of cavitation – in particular at the cellular level – are incompletely understood, in part due to the rapid bubble formation and strain rates of up to ~105–106 s–1 . This project aims to characterize material damage in 2D and 3D environments and cell cultures by utilizing digital image correlation at a speed of up to ten 6 frames per second.