Surface immobilizable chelator for label-free electrical detection of pyrophosphate

David J. Liu, Intel Corp., Santa Clara, CA
Grace M. Credo, Intel Corp., Santa Clara, CA
Xing Su, Intel Corp., Santa Clara, CA
Kai Wu, Intel Corp., Santa Clara, CA
Hsiao C. Lim, Intel Corp., Santa Clara, CA
Oguz H. Elibol, Purdue University
Rashid Bashir, University of Illinois at Urbana-Champaign
Madoo Varma, Intel Corp., Santa Clara, CA

Abstract

A new pyrophosphate (PPi) chelator was designed for surface-sensitive electrical detection of biomolecular reactions. This article describes the synthesis of the PPi-selective receptor, its surface immobilization and application to label-free electrical detection on a silicon-based field-effect transistor (FET) sensor.

Discipline(s)

Nanoscience and Nanotechnology