Biotemplated synthesis of metallic nanoparticle chains on an alpha-synuclein fiber scaffold

Robert Colby, Purdue University
J Hulleman, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University
Sonal Padalkar
J C. Rochet, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University
L Stanciu, Birck Nanotechnology Center and School of Materials Engineering, Purdue University

Date of this Version

February 2008

Citation

Journal of Nanoscience and Nanotechnology, Vol.8, 973–978, 2008

This document has been peer-reviewed.

 

Comments

Conference Information: International Workshop on Nanostructured Materials (ANAOMAT 2006)

Abstract

Biomolecular templates provide an excellent potential tool for bottom-up device fabrication. Self-assembling a-synuclein protein fibrils, the formation of which has been linked to Parkinson's disease, have yet to be explored for potential device fabrication. In this paper, a-synuclein fibrils were used as a template for palladium (Pd), gold (Au) and copper (Cu) nanoparticle chains synthesis. Deposition over a range of conditions resulted in metal-coated fibers with reproducible average diameters between 50 and 200 nm. Active elemental palladium deposited on the protein fibrils is used as a catalyst for the electroless deposition of Au and Cu. Nanoparticle chains were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray energy dispersive spectrometry (XEDS), and electron energy loss spectrometry (EELS).

 

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