Polymeric microdevices for transdermal and subcutaneous drug delivery

Manuel Ochoa, Birck Nanotechnology Center, Purdue University
Charilaos Mousoulis, Birck Nanotechnology Center, Purdue University
Babak Ziaie, Birck Nanotechnology Center, Purdue University

Abstract

Low cost manufacturing of polymeric microdevices for transdermal and subcutaneous drug delivery is slated to have a major impact on next generation devices for administration of biopharmaceuticals and other emerging new formulations. These devices range in complexity from simple microneedle arrays to more complicated systems incorporating micropumps, micro-reservoirs, on-board sensors, and electronic intelligence. In this paper, we review devices currently in the market and those in the earlier stages of research and development. We also present two examples of the research in our laboratory towards using phase change liquids in polymeric structures to create disposable micropumps and the development of an elastomeric reservoir for MEMS-based transdermal drug delivery systems. (C) 2012 Elsevier B.V. All rights reserved.

Discipline(s)

Nanoscience and Nanotechnology