Abstract
Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong two-photon luminescence (TPL) intensities, with a cos(4) dependence on the incident polarization. The TPL excitation spectrum can be superimposed onto the longitudinal plasmon band, indicating a plasmon-enhanced two-photon absorption cross section. The TPL signal from a single nanorod is 58 times that of the two-photon fluorescence signal from a single rhodamine molecule. The application of gold nanorods as TPL imaging agents is demonstrated by in vivo imaging of single nanorods flowing in mouse ear blood vessels.
Keywords
in vivo imaging; plasmon resonance; multiphoton; nonlinear optics, FLUORESCENCE CORRELATION SPECTROSCOPY; 2ND-HARMONIC GENERATION; ENHANCEMENT; MICROSCOPY; METALS; PHOTOLUMINESCENCE; GROWTH; NANOPARTICLES; EXCITATION; MECHANISM
Date of this Version
11-2005
Included in
Biomedical Engineering and Bioengineering Commons, Nanoscience and Nanotechnology Commons