The Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University provides knowledge on basic chemical and biological sciences for the improvement of human health.

This series contains publications from the Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University.

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Submissions from 2015

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Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius, Haroon Mohammad, P.V. N. Reddy, Dennis Monteleone, Abdelrahman S. Mayhoub, Mark S. Cushman, G. Kenitra Hammac, and Mohamed N. Seleem

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Reversible linkage of two distinct small molecule inhibitors of myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines, Jutta Wanner, Darlene Romashko, Douglas S. Werner, Earl W. May, Yue Peng, Ryan Schulz, Kenneth W. Foreman, Suzanne Russo, Lee D. Arnold, Maneesh R. Pingle, Donald E. Bergstrom, Francis Barany, and Stuart Thomson

Submissions from 2014

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PharmDock: A Pharmacophore-Based Docking Program, Bingjie Hu and Markus A. Lill

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IterTunnel; a Method for Predicting and Evaluating Ligand EgressTunnels in Proteins with Buried Active Sites, Laura J. Kingsley and Markus A. Lill

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A Genome-Wide Association Study Identifies a Locus on TERT for Mean Telomere Length in Han Chinese., Yun Liu, Lan Cao, Zhiqiang Li, Daizhan Zhou, Wanqing Liu, Qin Shen, Yanting Wu, Dan Zhang, Xun Hu, Ting Wang, Junyi Ye, Xiaoling Weng, Hong Zhang, Di Zhang, Zhou Zhang, Fatao Liu, Lin He, and Yongyong Shi

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Fibroblast Growth Factor Receptor Splice Variants are Stable Markers of Oncogenic Transforming Growth Factor β1 Signaling in Metastatic Breast Cancers., Michael K. Wendt, Molly A. Taylor, Barbara J. Schiemann, Khalid Sossey-Alaoui, and William P. Schiemann

Submissions from 2013

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Elevated Phospholipase A2 Activities in Plasma Samples from Multiple Cancers., Hui Cai, Elena G. Chiorean, Michael V. Chiorean, Douglas K. Rex, Bruce W. Robb, Noah M. Hahn, Ziyue Liu, Patrick J. Loehrer, Marietta L. Harrison, and Yan Xu

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Solvent Dependency of the UV-Vis Spectrum of Indenoisoquinolines: Role of Keto-Oxygens as Polarity Interaction Probes., Andrea Coletta, Silvia Castelli, Giovanni Chillemi, Nico Sanna, Mark S. Cushman, Yves Pommier, and Alessandro Desideri

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Epigenetic Regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA Methylation and Histone Modification., Baisheng Fu, Hongwei Wang, Jinhua Wang, Ivana Barouhas, Wanqing Liu, Adam Shuboy, David A. Bushinsky, Dongsheng Zhou, and Murray J. Favus

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Synthesis and Biological Evaluation of Novel Folic Acid Receptor-Targeted, β-Cyclodextrin-Based Drug Complexes for Cancer Treatment., Juan-Juan Yin, Sonali Sharma, Stepan P. Shumyak, Zhi-Xin Wang, Zhi-Wei Zhou, Yangde Zhang, Peixuan Guo, Chen-Zhong Li, Jagat R. Kanwar, Tianxin Yang, Shyam S. Mohapatra, Wanqing Liu, Wei Duan, Jian-Cheng Wang, Qi Li, Xueji Zhang, Jun Tan, Lee Jia, Jun Liang, Ming Q. Wei, Xiaotian Li, and Shu-Feng Zhou

Submissions from 2012

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Portable Bacterial Identification System Based on Elastic Light Scatter Patterns, Euiwon Bae, Dawei Ying, Donald Kramer, Valery Patsekin, Bartek Rajwa, Cheryl Holdman, Jennifer Sturgis, Vincent J. Davisson, and J Paul Robinson

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Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction., Giordano Mancini, Ilda D'Annessa, Andrea Coletta, Giovanni Chillemi, Yves Pommier, Mark S. Cushman, and Alessandro Desideri

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Anti-Malarial Activity of Geldanamycin Derivatives in Mice Infected with Plasmodium yoelii, Rubul Mout, Zhi-Dong Xu, Angela KH Wolf, Vincent J. Davisson, and Gotam K. Jarori

Submissions from 2011

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A Synergistic Antiproliferation Effect of Curcumin and Docosahexaenoic Acid in SK-BR-3 Breast Cancer Cells: Unique Signaling Not Explained by the Effects of Either Compound Alone., Jeffrey D. Altenburg, Andrew A. Bieberich, Colin Terry, Kevin A. Harvey, Justin F. VanHorn, Zhidong Xu, Vincent J. Davisson, and Rafat A. Siddiqui

Submissions from 2009

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Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR., Sean Ekins, Sandhya Kortagere, Manisha Iyer, Erica J. Reschly, Markus A. Lill, Matthew R. Redinbo, and Matthew D. Krasowski

Submissions from 2003

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Riboflavin Synthase of Schizosaccharomyces pombe. Protein Dynamics Revealed by 19F NMR Protein Perturbation Experiments., Markus Fischer, Ann-Kathrin Schott, Kristina Kemter, Richard Feicht, Gerald Richter, Boris Illarionov, Wolfgang Eisenreich, Stefan Gerhardt, Mark S. Cushman, Stefan Steinbacher, Robert Huber, and Adelbert Bacher