The Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University provides knowledge on basic chemical and biological sciences for the improvement of human health.
This series contains publications from the Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University.
Submissions from 2022
RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1, Kyle E. Harvey, Emily K. LaVigne, Mohd Saleem Dar, Amy E. Salyer, Evan P. S. Pratt, Paxton A. Simple, Uma K. Aryal, Humaira Gowher, and Gregory H. Hockerman
Regulator of G protein signaling 2 inhibits Gαq-dependent uveal melanoma cell growth, Qian Zhang, Andrew J. Haak, and Benita Sjogren
Submissions from 2020
Aprepitant, An Antiemetic Agent, Interferes with Metal Ion Homeostasis of Candida Auris and Displays Potent Synergistic Interactions With Azole Drugs, Hassan E. Eldesouky, Nadia A. Lanman, Tony Hazbun, and Mohamed N. Seleem
Ospemifene Displays Broad-Spectrum Synergistic Interactions with Itraconazole Through Potent Interference with Fungal Efflux Activities, Hassan E. Eldesouky, Ehab A. Salama, Tony R. Hazbun, Abdelrahman S. Mayhoub, and Mohamed N. Seleem
Repurposing Approach IdentifiesPitavastatin as a Potent AzoleChemosensitizing Agent EffectiveAgainst Azole-Resistant CandidaSpecies, Hassan E. Eldesouky, Ehab A. Salama, Xiaoyan Li, Tony R. Hazbun, Abdelrahman S. Mayhoub, and Mohamed N. Seleem
Submissions from 2019
Inferring Gene RegulatoryNetworks from a Populationof Yeast Segregants, Chen Chen, Tony R. Hazbun, and Min Zhang
Antibiotic-induced Decreases inthe Levels of Microbial-derivedShort-chain Fatty Acids Correlatewith Increased GastrointestinalColonization of Candida Albicans, Jack Guinan, Shaohua Wang, Tony R. Hazbun, Hariom Yadav, and Shankar Thangamani
Identification of a PhenylthiazoleSmall Molecule with DualAntifungal and Antibiofilm ActivityAgainst Candida albicans andCandida auris, Haroon Mohammad, Hassan E. Eldesouky, Tony R. Hazbun, Abdelrahman S. Mayhoub, and Mohamed N. Seleem
Submissions from 2017
Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway, Shankar Thangamani, Matthew Maland, Haroon Mohammad, Pete E. Pascuzzi, Larisa Avramova, Carla E. Koehler, Tony R. Hazbun, and Mohamed N. Seleem
Submissions from 2016
Hsp31, A Member of the DJ-1 Superfamily, is a multitaskingstress responder with chaperone activity, Kiran Aslam and Tony R. Hazbun
The Small Heat Shock Protein Hsp31 Cooperates with Hsp104 to Modulate Sup35 Prion Aggregation, Kiran Aslam, Chai-Jui Tsai, and Tony R. Hazbun
Unique behavioral and neurochemical effects induced by repeated adolescent consumption of caffeine-mixed alcohol in C57BL/6 mice., Meridith T. Robins, Julie Lu, and Richard M. Van Rijn
Submissions from 2015
Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease, Soumira Ghosh and Robert Geahlen
Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius, Haroon Mohammad, P.V. N. Reddy, Dennis Monteleone, Abdelrahman S. Mayhoub, Mark S. Cushman, G. Kenitra Hammac, and Mohamed N. Seleem
The Mps1 Kinase Modulates the Recruitment and Activity of Cnn1CENP-T at Saccharomyces cerevisiae Kinetochores, Kriti Shrestha Thapa, Amanda Oldani, Cinzia Pagliuca, Peter De Wulf, and Tony R. Hazbun
Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process, Chai-Jui Tsai, Kiran Aslam, Holli M. Drendel, Josephat M. Asiago, Kourtney M. Goode, Lake N. Paul, Jean-Christophe Rochet, and Tony R. Hazbun
Reversible linkage of two distinct small molecule inhibitors of myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines, Jutta Wanner, Darlene Romashko, Douglas S. Werner, Earl W. May, Yue Peng, Ryan Schulz, Kenneth W. Foreman, Suzanne Russo, Lee D. Arnold, Maneesh R. Pingle, Donald E. Bergstrom, Francis Barany, and Stuart Thomson
The Antitumorigenic Function of EGFR in Metastatic Breast Cancer is Regulated by Expression of Mig6, Michael Wendt, Whitney K. Williams, Pete E. Pascuzzi, Nikolas G. Balanis, Barbara J. Schiemann, Cathleen R. Carlin, and William P. Schiemann
Submissions from 2014
PharmDock: A Pharmacophore-Based Docking Program, Bingjie Hu and Markus A. Lill
IterTunnel; a Method for Predicting and Evaluating Ligand EgressTunnels in Proteins with Buried Active Sites, Laura J. Kingsley and Markus A. Lill
A Genome-Wide Association Study Identifies a Locus on TERT for Mean Telomere Length in Han Chinese., Yun Liu, Lan Cao, Zhiqiang Li, Daizhan Zhou, Wanqing Liu, Qin Shen, Yanting Wu, Dan Zhang, Xun Hu, Ting Wang, Junyi Ye, Xiaoling Weng, Hong Zhang, Di Zhang, Zhou Zhang, Fatao Liu, Lin He, and Yongyong Shi
Fibroblast Growth Factor Receptor Splice Variants are Stable Markers of Oncogenic Transforming Growth Factor β1 Signaling in Metastatic Breast Cancers., Michael K. Wendt, Molly A. Taylor, Barbara J. Schiemann, Khalid Sossey-Alaoui, and William P. Schiemann
Submissions from 2013
Elevated Phospholipase A2 Activities in Plasma Samples from Multiple Cancers., Hui Cai, Elena G. Chiorean, Michael V. Chiorean, Douglas K. Rex, Bruce W. Robb, Noah M. Hahn, Ziyue Liu, Patrick J. Loehrer, Marietta L. Harrison, and Yan Xu
Solvent Dependency of the UV-Vis Spectrum of Indenoisoquinolines: Role of Keto-Oxygens as Polarity Interaction Probes., Andrea Coletta, Silvia Castelli, Giovanni Chillemi, Nico Sanna, Mark S. Cushman, Yves Pommier, and Alessandro Desideri
Epigenetic Regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA Methylation and Histone Modification., Baisheng Fu, Hongwei Wang, Jinhua Wang, Ivana Barouhas, Wanqing Liu, Adam Shuboy, David A. Bushinsky, Dongsheng Zhou, and Murray J. Favus
Synthesis and Biological Evaluation of Novel Folic Acid Receptor-Targeted, β-Cyclodextrin-Based Drug Complexes for Cancer Treatment., Juan-Juan Yin, Sonali Sharma, Stepan P. Shumyak, Zhi-Xin Wang, Zhi-Wei Zhou, Yangde Zhang, Peixuan Guo, Chen-Zhong Li, Jagat R. Kanwar, Tianxin Yang, Shyam S. Mohapatra, Wanqing Liu, Wei Duan, Jian-Cheng Wang, Qi Li, Xueji Zhang, Jun Tan, Lee Jia, Jun Liang, Ming Q. Wei, Xiaotian Li, and Shu-Feng Zhou
Submissions from 2012
Portable Bacterial Identification System Based on Elastic Light Scatter Patterns, Euiwon Bae, Dawei Ying, Donald Kramer, Valery Patsekin, Bartek Rajwa, Cheryl Holdman, Jennifer Sturgis, Vincent J. Davisson, and J Paul Robinson
Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction., Giordano Mancini, Ilda D'Annessa, Andrea Coletta, Giovanni Chillemi, Yves Pommier, Mark S. Cushman, and Alessandro Desideri
Anti-Malarial Activity of Geldanamycin Derivatives in Mice Infected with Plasmodium yoelii, Rubul Mout, Zhi-Dong Xu, Angela KH Wolf, Vincent J. Davisson, and Gotam K. Jarori
Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic Cancer, Bing Song, X Shawn Liu, Steven J. Rice, Shihuan Kuang, Bennett D. Elzey, Stephen F. Konieczny, Timoty L. Ratliff, Tony R. Hazbun, Elena G. Chiorean, and Xiaoqi Liu
Submissions from 2011
A Synergistic Antiproliferation Effect of Curcumin and Docosahexaenoic Acid in SK-BR-3 Breast Cancer Cells: Unique Signaling Not Explained by the Effects of Either Compound Alone., Jeffrey D. Altenburg, Andrew A. Bieberich, Colin Terry, Kevin A. Harvey, Justin F. VanHorn, Zhidong Xu, Vincent J. Davisson, and Rafat A. Siddiqui
Submissions from 2009
Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR., Sean Ekins, Sandhya Kortagere, Manisha Iyer, Erica J. Reschly, Markus A. Lill, Matthew R. Redinbo, and Matthew D. Krasowski
Submissions from 2007
A Protein Interaction Map of the Mitotic Spindle, Jonathan Wong, Yuko Nakajima, Stefan Westermann, Ching Shang, Jung-Seog Kang, Crystal Goodner, Pantea Houshmand, Stanley Fields, Clarence S.M. Chan, David Drubin, Georjana Barnes, and Tony R. Hazbun
Submissions from 2006
Sumoylation of The Budding Yeast Kinetochore Protein Ndc10 is Required for Ndc10 Spindle Localization and Regulation of Anaphase Spindle Elongation, Ben Montpetit, Tony R. Hazbun, Stanley Fields, and Philip Hieter
Submissions from 2003
Riboflavin Synthase of Schizosaccharomyces pombe. Protein Dynamics Revealed by 19F NMR Protein Perturbation Experiments., Markus Fischer, Ann-Kathrin Schott, Kristina Kemter, Richard Feicht, Gerald Richter, Boris Illarionov, Wolfgang Eisenreich, Stefan Gerhardt, Mark S. Cushman, Stefan Steinbacher, Robert Huber, and Adelbert Bacher