Development of a model of pars esophageal ulceration in swine reflecting factors associated with modern production practices

Bradley Van Lawrence, Purdue University

Abstract

Experiments were conducted to evaluate the relative influence of fasting, transportation, restraint, diet particle size, and weaning on the development of PE (PE) ulceration in pigs. Initial experiments were conducted with 60 kg pigs that were meal fed. A 24-h fast induced keratinization and partial erosion of the PE epithelium. Feeding a 550 $\mu$m diet maintained fasting-induced PE tissue damage. Feeding a 750 $\mu$m diet for as little as 3 d following a 24-h fast was sufficient to allow for nearly complete healing of the fasting-induced PE tissue damage, with complete healing observed when a 750 $\mu$m diet was fed for 28 d. Following transportation and a 24-h fast, at least 7 d of feeding a 750 $\mu$m diet was required before healing of fasting-induced PE tissue damage was observed. Additional experiments were conducted using newly weaned pigs either euthanatized at weaning, following weaning and a 24-h fast, or following weaning, a 24-h fast, and feeding of a 750 or 550 $\mu$m diet for 28 d. Pigs euthanatized at weaning had a normal PE tissue appearance. Pigs euthanatized following weaning and a 24-h fast had keratinization and partial erosion of the PE tissue similar to that observed with 60 kg pigs fasted for 24 h. Feeding a 550 $\mu$m diet for 28 d maintained the level of PE tissue damage induced by weaning followed by a 24-h fast. Feeding a 750 $\mu$m diet for 28 d resulted in nearly complete healing of the PE tissue damage induced by weaning followed by a 24-h fast. The influence of either dietary zinc (100 or 3,000 ppm Zn), or intraperitoneal injection of 22 or 88 mg zinc sulphate/kg BW on PE ulceration induced by weaning followed by a 24-h fast was investigated. Addition of 100 or 3,000 mg supplemental zinc to a 550 $\mu$m diet did not allow for healing of the weaning and fasting-induced PE tissue damage. Intraperitoneal injection of 22 or 88 mg zinc sulphate 12, 24 or 48 h prior to weaning did not influence the degree of PE tissue damage induced by weaning followed by a 24-h fast.

Degree

Ph.D.

Advisors

Adeola, Purdue University.

Subject Area

Livestock|Veterinary services|Animal diseases

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