Fluid and solid mechanics of vascular devices: Potential mechanism of vascular remodeling
Abstract
The fluid and solid mechanics surrounding medical devices influence tissue remodeling and disease progression. This dissertation work centers on mechanics of vascular devices, focusing on vascular stent and aortic clamp. The overall objective was to investigate the fluid and solid mechanics of vascular devices and how the mechanics affect tissue remodeling or injury. Stent implantations were simulated for various stent sizing cases. The effects of fluid wall shear stresses and solid wall stresses on tissue remodeling such as neointimal hyperplasia were investigated in swine experiments. Furthermore, the influences of stenting at various vascular bifurcations were studied and the clinical impact elucidated. Finally, the effects of device design features were investigated for aortic cross-clamping and the implications for vascular injury were examined. The work in this dissertation shed light on the influences of fluid and solid mechanics on disease processes and will lead to better device design/deployment and clinical outcome.
Degree
Ph.D.
Advisors
Kassab, Purdue University.
Subject Area
Biomedical engineering|Biomechanics
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