Studies toward the total synthesis of apoptolidin analogues
Abstract
A comprehensive study toward the synthesis of Apoptolidin analogues have been carried out. Synthesis of macrocyclic section of Apoptolidin D was carried out successfully using a combination of HWE for the formation of C6-C7 olefin, and a Suzuki cross coupling protocol for generating the ( E,E)-diene segment. A selective glycosylation protocol was achieved on the C-27 alcohol of modified Apoptolidin. The glycosylated southern part and non-glycosylated northern part were combined to produce the advanced intermediate of apoptolidin in preliminary studies. The completion of synthesis of various analogues and testing their biological activity constitute the future goals.
Degree
Ph.D.
Advisors
Fuchs, Purdue University.
Subject Area
Organic chemistry
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