Miniaturization of the ion trap mass spectrometer
Abstract
The development of miniature ion trap mass spectrometers has been an active area, fueled by the promising analytical capabilities and the convenience of fast in situ analysis with portable instruments. The objective is to miniaturize mass spectrometers in weight, size, and power consumption while retaining the advantages and analytical capabilities of mass spectrometry at the same time. The thesis focuses on the instrumentation of miniature ion trap mass spectrometers, including ionization, ion transfer, mass analyzer, ion detection and related vacuum and electronic techniques. The work presented represents recent progress achieved in miniature ion trap mass spectrometers. The development of two miniature mass spectrometers, a 10 kg Mini 10 mass spectrometer with electron impact ionization source, developed in 2005 and a 5 kg Mini 11 mass spectrometer with multiple ionization sources, developed in 2008, is introduced. The momentum and reasons driving the development from the Mini 10 to the Mini 11 are depicted, and the technical details of key components are discussed. Special focus is given to a glow discharge electron impact ionization source, which is an ideal substitute for the filament electron source used in the electron impact ionization, and a discontinuous atmospheric pressure interface, which enables the implementation of atmospheric pressure ionization sources in miniature ion trap mass spectrometers with limited pumping capabilities.
Degree
Ph.D.
Advisors
Cooks, Purdue University.
Subject Area
Analytical chemistry
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