A physiologically-based pharmacokinetic (PBPK) model for ethanol: Mathematical foundations, parameter estimation, and other applications

Martin Henry Plawecki, Purdue University

Abstract

A physiologically-based pharmacokinetic (PBPK) model for the distribution and elimination of ethanol from the human body, implemented within Simulink ®, has been used for many years to estimate the alcohol infusion profile required to produce a specific breath alcohol concentration (BrAC) time course. The mathematical foundations and interrelations of this model will be elaborated. Parameter identification will be discussed using two distinct methods; a statistical measurement model method and an experimental data reconstruction method. Further, the methodology of model parameter value prediction will be discussed and improved using the latter parameter identification procedure, the result of which is better a priori control over systemic exposure. Finally, characterization of oral intake and the potential heritability of identified parameter values will be discussed. ^

Degree

Ph.D.

Advisors

Major Professors: Peter C. Doerschuk, Purdue University, Sean O'Connor, Purdue University.

Subject Area

Engineering, Biomedical|Health Sciences, Pharmacy

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