Design and dynamic modeling of simulated moving bed processes for multicomponent biochemical separations
Abstract
Four-zone simulated moving bed (SMB) processes have been used widely for isolating two pure products from two-component mixtures under ideal (high-efficiency) conditions. In many such cases, the uptake of solutes on the sorbent is described by a linear distribution coefficient. But many systems require the separation of more than two components, are operated under nonideal (low-efficiency) conditions, or have nonlinear uptake. In light of these challenges, generalized design strategies were investigated here for splitting multicomponent mixtures. The “standing wave” analysis for binary mixtures [76] was extended in this study to achieve any specified split of a mixture containing three or more components under nonideal conditions. Aspects of multicomponent fractionation and gradient were isolated and studied systematically. A four-component mixture of glucose, xylose, acetic acid, and sulfuric acid was chosen as an example to illustrate strategies for continuous multicomponent fractionation in a nonideal, linear system. This multicomponent fractionation strategy was validated on a laboratory-scale, low-pressure SMB system for the separation of three amino acids. These approaches point the way to a design procedure for SMB fractionation of a multicomponent, nonlinear, nonideal system with thermal gradients. Rate model simulations confirm that the standing wave design guarantees high purity and high yield for these separations.
Degree
Ph.D.
Advisors
Wang, Purdue University.
Subject Area
Chemical engineering
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